Men and postmenopausal women with iron deficiency had increased risk for gastrointestinal malignancy.

(2002) Am J Med 113, 276. Ioannou GN, Rockey DC, Bryson CL, Weiss NS. . Iron deficiency and gastrointestinal malignancy: a population-based cohort study. . ; . : . –80 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: Does iron deficiency, with or without anaemia, increase the risk of gastrointestinal malignancy? Cohort study with 2 years of follow up. USA. 9024 civilian, non-institutionalised persons 25–74 years of age (60% women, 83% white) who participated in the National Health and Nutrition Examination Survey (NHANES I) and the NHANES I Epidemiologic Followup Study (NHEFS). Exclusion criteria were a history of cancer reported during NHANES I and missing iron saturation and haemoglobin measurements at baseline. Baseline data were collected on iron deficiency (iron saturation <15%) and anaemia (haemoglobin concentration <5th percentile for each age and sex group). Separate analyses were done for premenopausal women, men and postmenopausal women, age ≥50 years, and age ≥65 years. Within each group, participants were grouped into 4 diagnostic categories based … [1]: {openurl}?query=rft.jtitle%253DThe%2BAmerican%2Bjournal%2Bof%2Bmedicine%26rft.stitle%253DAm%2BJ%2BMed%26rft.aulast%253DIoannou%26rft.auinit1%253DG.%2BN.%26rft.volume%253D113%26rft.issue%253D4%26rft.spage%253D276%26rft.epage%253D280%26rft.atitle%253DIron%2Bdeficiency%2Band%2Bgastrointestinal%2Bmalignancy%253A%2Ba%2Bpopulation-based%2Bcohort%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0002-9343%252802%252901214-7%26rft_id%253Dinfo%253Apmid%252F12361812%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0002-9343(02)01214-7&link_type=DOI [3]: /lookup/external-ref?access_num=12361812&link_type=MED&atom=%2Febmed%2F8%2F3%2F94.atom [4]: /lookup/external-ref?access_num=000178319500002&link_type=ISI