Non-benzimidazole containing inhibitors of respiratory syncytial virus.

David C Pryde,Thien-Duc Tran,Iain Gardner,Helen Bright,Paul Stupple,Sebastien Galan,Liam Alsop,Lesa Watson,Donald S Middleton,Satish Dayal,Michelle Platts,Edward J Murray,Tanya Parkinson,Robert Webster

Bioorganic & Medicinal Chemistry Letters（2013）

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摘要

Several non-benzimidazole containing inhibitors of respiratory syncytial virus are described. Core template modification, analysis of antiviral activity, physicochemistry and optimisation of properties led to the thiazole-imidazole 13, that showed a good potency and pharmacokinetic profile in the rat.

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关键词

RSV,Virus,Benzimidazole,Antiviral,Heterocycle

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