New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation.
ORGANIC & BIOMOLECULAR CHEMISTRY（2013）
Abstract
Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.
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Key words
ale formation
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