Novel 5-Cyclopropyl-1,4-benzodiazepin-2-ones As Potent and Selective IKs-blocking Class III Antiarrhythmic Agents
Bioorganic & medicinal chemistry letters(2003)
Abstract
Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones having various N-l substituents were identified as potent and selective blockers of the slowly activating cardiac delayed rectifier potassium current (IKs). Compound 11 is the most potent IKs channel blocker reported to date.
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Key words
Potassium Channels
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