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Novel 5-Cyclopropyl-1,4-benzodiazepin-2-ones As Potent and Selective IKs-blocking Class III Antiarrhythmic Agents

JW Butcher,NJ Liverton,DA Claremon,RM Freidinger,NK Jurkiewicz,JJ Lynch,JJ Salata,JX Wang,CM Dieckhaus,DE Slaughter,K Vyas

Bioorganic & medicinal chemistry letters（2003）

Cited 21|Views5
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Abstract
Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones having various N-l substituents were identified as potent and selective blockers of the slowly activating cardiac delayed rectifier potassium current (IKs). Compound 11 is the most potent IKs channel blocker reported to date.
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Potassium Channels
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