From a cytotoxic agent to the discovery of a novel antimalarial agent.

Ravi S P Singh,Umashankar Das,Jennifer M Auschwitz,Susan E Leed,Mark R Hickman,Jonathan R Dimmock,Jane Alcorn

Bioorganic & Medicinal Chemistry Letters（2013）

Cited 3|Views3

No score

Abstract

The cytotoxic agent 2 displays potent antimalarial properties towards drug-sensitive as well as drug-resistant strains of Plasmodium falciparum. It concentrates in erythrocytes where it lowers the concentration of glutathione and displays adequate permeability characteristics across the CACO-2 monolayer.

Translated text

Key words

Antimalarial,3,5-Bis(benzylidene)-4-piperidones,CACO-2 cells,Drug resistance,Glutathione,Plasmodium falciparum

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined