A 75-Year-Old Female Patient With Pleural Effusion And Gastric Metastases Of A Poorly Differentiated Carcinoma

INTERNIST(2013)

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Abstract
A 75-year-old woman was found to have left-sided pleural effusion and endoscopy revealed the rare entity of adenoid cystic carcinoma metastases in the gastric mucosa. Approximately 20 % of patients with this carcinoma suffer from distant metastases. For the initial staging detection of adenoid cystic carcinoma metastasis with positron emission tomography (PET) or PET computed tomography (CT) is recommended. The recurrent t(6;9)(q22-23;p23-24) translocation that results in a fusion of the two transcription factor genes MYB and NFIB is detectable in half of the cases. As in our case molecular pathology can confirm the correct diagnosis and identification of the localization of the primary tumor.
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Key words
Carcinoma, adenoid cystic, Salivary gland, Endoscopy, Pathology, molecular, MYB-NFIB fusion protein, human
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