3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR2.

Igor A Schepetkin,Liliya N Kirpotina,Andrei I Khlebnikov,Marcello Leopoldo,Ermelinda Lucente,Enza Lacivita,Paola De Giorgio,Mark T Quinn

Biochemical Pharmacology（2013）

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摘要

Stereoselective binding of chiral FPR2 agonists. “Active” (top) and “inactive” (bottom) templates of FPR2 chiral agonists (side and rear views) are shown.

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关键词

Enantiomer,N-formyl peptide receptor,G protein-coupled receptor,Agonist,Chiral recognition

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