Painting Proteins Blue: Beta-(1-Azulenyl)-L-Alanine As A Probe For Studying Protein-Protein Interactions

Yurii S. Moroz,Wolfgang Binder,Patrik Nygren,Gregory A. Caputo,Ivan V. Korendovych

CHEMICAL COMMUNICATIONS（2013）

引用 40|浏览3

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摘要

We demonstrated that beta-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor protein-protein interactions while not perturbing them.

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关键词

myosin light chain kinase,calmodulin,fluorescence resonance energy transfer,proteins,protein binding

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