[The experimental study of expression of intercellular adhesion molecule-1 after fluid percussion brain injury].

OBJECTIVE:To determine the changes of intercellular adhesion molecule-1 after traumatic brain injury. METHODS:Use the fluid-percussion model to inflict rat brain and take the samples at 2, 4, 8, 12, 24 hours after brain injury. The samples were studied by immunohistochemistry method combined with image analysis by MIAS image analysis system. RESULT:The expression of ICAM-1 upregulates at 2 hours, reaches peak at 12 hours and falls down at 24 hours after brain injury. CONCLUSION:The changes of ICAM-1 in brain can provide a backup for estimation of injury time and survival period after brain injury which sustained within 24 hours.