Recombination-restarted replication makes inverted chromosome fusions at inverted repeats
NATURE(2012)
摘要
new mechanism of chromosomal rearrangement is identified through the observation that broken or collapsed DNA replication forks restarted by homologous recombination have a high propensity for U-turns at short inverted repeats; the error-prone nature of this mechanism is suggested to contribute to gross chromosomal rearrangements and copy-number variations present in cancer and other genomic disorders.
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关键词
DNA damage checkpoints, Stalled forks, DNA recombination, Mechanisms of disease
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