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125I-青藤碱大鼠经皮渗透试验研究

张宁,徐莲英,徐培康,钟高仁

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials（2002）

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Abstract
目的:阐明125I-青藤碱经大鼠皮肤给药后渗透和扩散的走向.方法:采用同位素岱I-标记青藤碱,涂于大鼠颈部皮肤,在一定时间内测定125I-青藤碱在皮下纵向渗透的深度和横向扩散的范围.结果:mI-青藤碱纵向扩散可达颈椎骨部,横向扩散可达2 cm2范围,无论是横向还是纵向扩散均呈现出明显的浓度梯度.结论:瞄I-青藤碱不仅可以透皮吸收入血发挥全身作用也可在皮肤表面蓄积发挥局部作用.
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transdermal delivery way,permeability,i-sinomenine
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