Abnormal development of NG2 + PDGFR-α + neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model

Hydrocephalus is a neurological disorder characterized by expansion of the ventricles. In a mouse model, the authors identified a role for neural progenitors and for platelet-derived growth factor signaling in the pathogenesis of neonatal hydrocephalus. Targeting this pathway reduced ventricular volume, pointing to a new therapeutic target for this condition.