Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David C Whitcomb,Jessica LaRusch,Alyssa M Krasinskas,Lambertus Klei,Jill P Smith,Randall E Brand,John P Neoptolemos,Markus M Lerch, Matt Tector,Bimaljit S Sandhu,Nalini M Guda,Lidiya Orlichenko,Marilyn S Albert,Samer Alkaade,Stephen T Amann,Michelle A Anderson,John Baillie,Peter A Banks,Darwin Conwell,Gregory A Coté,Peter B Cotton,James DiSario,Lindsay A Farrer,Chris E Forsmark,Marianne Johnstone,Timothy B Gardner,Andres Gelrud,William Greenhalf,Jonathan L Haines,Douglas J Hartman,Robert A Hawes,Christopher Lawrence,Michele Lewis,Julia Mayerle,Richard Mayeux,Nadine M Melhem,Mary E Money,Thiruvengadam Muniraj,Georgios I Papachristou,Margaret A Pericak-Vance,Joseph Romagnuolo,Gerard D Schellenberg,Stuart Sherman,Peter Simon,Vijay P Singh,Adam Slivka,Donna Stolz,Robert Sutton,Frank Ulrich Weiss,C Mel Wilcox,Narcis Octavian Zarnescu,Stephen R Wisniewski,Michael R O'Connell,Michelle L Kienholz,Kathryn Roeder,M Michael Barmada,Dhiraj Yadav,Bernie Devlin

NATURE GENETICS（2012）

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摘要

David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide association study of pancreatitis. They identify common variants at two loci associated with risk of this disease, including one on the X chromosome that shows strong evidence of interaction with alcohol consumption.

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关键词

common genetic variants,genetic variants,cldn2,alcohol-related

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