Gender bias in autoimmune diseases: X chromosome inactivation in women with multiple sclerosis.
Journal of the neurological sciences(2009)
摘要
The majority of autoimmune disorders are characterized by female predominance. Several mechanisms have been proposed as explanations for this gender bias, among them X chromosome inactivation. An increased frequency of skewed X inactivation has been found in some autoimmune disorders, like scleroderma and autoimmune thyroid disease, and may thus offer a possible explanation for the female predominance. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with pathological features of an autoimmune disorder. The incidence of MS in females is approximately twofold compared to the incidence in males. X inactivation does not seem to be part of the explanation for the gender bias in MS. This paper reviews the possible role of X chromosome inactivation in some autoimmune diseases, and describes a recent study of X inactivation in females with MS.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要