Enhanced sodium-calcium exchange in the infarcted heart: effects on sarcoplasmic reticulum content and cellular contractility.
CELLULAR AND MOLECULAR PHYSIOLOGY OF SODIUM-CALCIUM EXCHANGE(2006)
摘要
Arrhythmias and contractile dysfunction both contribute to the high morbidity and mortality in patients with congestive heart failure. Contractile dysfunction is generally believed to reflect a decrease in the amplitude of intracellular Ca2+ transients, whereas tachyarrythmias are often initiated in the setting of cellular Ca2+ overload. In a rabbit model of left ventricular dysfunction due to myocardial infarction, we found evidence that myocyte sarcoplasmic reticulum Ca2+ content may be normal or even increased at slow stimulation rates. This may occur because prolonged action potential duration promotes Ca2+ influx via the Na+/Ca2+ exchanger. Despite preserved SR Ca2+ content, intracellular Ca2+ transients and contractions may be reduced in amplitude because of impaired synchronization of Ca2+ release events throughout the myocyte.
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关键词
Na/Ca exchange,infarcted heart,sarcoplasmic reticulum,cellular contractility
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