Treatment of HIV infection with raltegravir.
EXPERT OPINION ON PHARMACOTHERAPY(2009)
摘要
Background: Raltegravir, an inhibitor of the HIV-1 integrase enzyme, is now available for the treatment of drug-resistant virus. Objective: To establish raltegravir as an effective addition to the existing antiretroviral armamentarium by reviewing pharmacokinetics, efficacy, safety and tolerability. Methods: Data from pharmacokinetic, Phase II and III clinical trials were reviewed. Results/conclusions: Results from clinical trials indicate that raltegravir is safe and highly effective in the treatment of both antiretroviral-naive and -experienced patients.
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关键词
antiretroviral therapy,HIV,human immunodeficiency virus,integrase inhibitor,raltegravir
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