Caught in the Act: Reprogramming of Adipocytes into Lymph-Node Stroma

Interactions between stromal organizer cells and hematopoietic lymphoid inducer cells initiate lymph-node formation. In this issue of Immunity, Bénézech et al. demonstrate that adipocyte precursors give rise to lymph-node stromal organizer cells, illuminating an important step in lymphoid-tissue development.