In vivo activity of an azole series of CCR2 antagonists.

Chris A Smethurst,Nicola Bevan,Carl Brooks,Amanda Emmons,Peter J Gough,Claudette Mookherjee,Kitty Moores,Simon Peace,Joanne Philp,Val Piercy,Steve P Watson,Mara Zippoli

Bioorganic & Medicinal Chemistry Letters（2012）

引用 4|浏览6

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摘要

Optimisation of a series of biaryl sulphonamides resulted in the identification of compound 7 which demonstrated dose-dependent and strain-specific inhibition of monocyte recruitment in a thioglycollate-induced peritonitis model of inflammation.

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关键词

CCR2,CCL2,Chemokine,Antagonists,Sulphonamides

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