Challenges in structural modeling of RNA-protein interactions
Current Opinion in Structural Biology(2023)
Abstract
In the past few years, the number of RNA-binding proteins (RBP) and RNA-RBP interactions has increased significantly. Here, we review recent developments in the methodology for protein-RNA and protein-protein complex structure modeling with deep learning and co-evolution, as well as discuss the challenges and opportunities for building a reliable approach for protein-RNA complex structure modelling. Protein Data bank (PDB) and Cross-linking immunoprecipitation (CLIP) data could be combined together and used to infer 2D geometry of protein-RNA interactions by deep learning.
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Key words
structural modeling,rna-protein
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