Modeling biological activities of nanoparticles.
NANO LETTERS(2012)
摘要
Products are increasingly incorporating nanomaterials, but we have a poor understanding of their adverse effects. To assess risk, regulatory authorities need more experimental testing of nanoparticles. Computational models play a complementary role in allowing rapid prediction of potential toxicities of new and modified nanomaterials. We generated quantitative, predictive models of cellular uptake and apoptosis induced by nanoparticles for several cell types. We illustrate the potential of computational methods to make a contribution to nanosafety.
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关键词
Nanoparticle toxicity,model prediction,apoptosis,cellular uptake,Bayesian methods
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