T1|[sol]|ST2 promotes T helper 2 cell activation and polyfunctionality in bronchopulmonary mycosis
MUCOSAL IMMUNOLOGY(2013)
Abstract
Interleukin (IL)-33 enhances T helper (Th)2 immunity via its receptor T1/ST2. Infection with the yeast-like pathogen Cryptococcus neoformans is usually controlled by a Th1-mediated immune response. The mechanisms responsible for nonprotective Th2 immunity leading to allergic inflammation in pulmonary cryptococcosis are still not fully understood. Using a murine pulmonary model of C. neoformans infection, we report that T1/ST2 expression correlates with the intensity of Th2 activation, as demonstrated by the expression of CD25 and CD44 and downregulation of CD62L. Antigen-specific T1/ST2+ Th cells are the primary source of the Th2 cytokines IL-5 and IL-13 as compared with wild-type T1/ST2− Th cells or Th cells from T1/ST2−/− mice. In addition, T1/ST2+ Th cells almost exclusively contain bi- and trifunctional Th2 cytokine-producing Th cells compared with T1/ST2− Th cells or Th cells from T1/ST2−/− mice. Finally, T1/ST2-driven Th2 development resulted in defective pulmonary fungal control. These data demonstrate that T1/ST2 directs Th2 cell activation and polyfunctionality in allergic bronchopulmonary mycosis.
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Key words
Mucosal Immunology, Society of Mucosal Immunology, SMI, immunity, inflammation, mucosal tissues, gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, genitourinary, immunology, basic studies, translational studies, clinical studies
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