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Efficient three-component Strecker reaction of aldehydes/ketones via NHC-amidate palladium(II) complex catalysis.

Jamie Jarusiewicz,Yvonne Choe,Kyung Soo Yoo,Chan Pil Park,Kyung Woon Jung

The Journal of organic chemistry（2009）

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Abstract
A simple and efficient one-pot, three-component method has been developed for the synthesis of alpha-aminonitriles. This Strecker reaction is applicable for aldehydes and ketones with aliphatic or aromatic amines and trimethylsilyl cyanide in the presence of a palladium Lewis acid catalyst in dichloromethane solvent at room temperature.
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