Neonatal desensitization does not universally prevent xenograft rejection

To the Editor: Human cells transplanted into immunocompetent animals are generally rejected within 2–4 weeks1. Severe immune suppression is capable of protecting the grafted cells; however, such treatment is associated with unacceptable side effects2. An important advancement in the field was the introduction of immunodeficient animal models that accept xenografts, but… Download references