Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.

Bioorganic & Medicinal Chemistry Letters（2013）

引用 22|浏览19

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摘要

Previous medicinal chemistry efforts identified a series of phenylalanine derivatives as GPR142 agonists. Optimization of this series led to a tool compound 22, which showed in vivo efficacy in mice with dose-dependent increase in insulin secretion and a decrease in glucose levels.

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关键词

GPR142 agonist,Type II diabetes,Glucose-lowering,Insulin secretagogue

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