Facile synthesis of colorimetric histone deacetylase substrates.

Alexander Dose,Jan Oliver Jost,Antje C Spieß,Petra Henklein,Michael Beyermann,Dirk Schwarzer

CHEMICAL COMMUNICATIONS（2012）

Cited 9|Views8

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Abstract

Here we report a simple procedure for generating colorimetric histone deacetylase (HDAC) substrates by solid-phase peptide synthesis based on racemization-free couplings of amino acid chlorides. We demonstrate the applicability of these substrates in HDAC assays.

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Key words

colorimetric histone deacetylase substrates,facile synthesis

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