Synthetic lethality between Rb, p53 and Dicer or miR-17–92 in retinal progenitors suppresses retinoblastoma formation

David Nittner,Irina Lambertz,Frederic Clermont,Pieter Mestdagh, Corinna Köhler,Søren Jensby Nielsen,Aart Jochemsen,Frank Speleman,Jo Vandesompele,Michael A. Dyer,Alexander Schramm,Johannes H. Schulte,Jean-Christophe Marine

NATURE CELL BIOLOGY（2012）

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摘要

Marine and colleagues use mouse models to show that loss of Dicer or its downstream microRNA cluster miR-17–92 in retinal progenitors prevents retinoblastoma formation through a synthetic lethal interaction with Rb and p53 deficiency.

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关键词

retinal progenitors suppresses,p53,synthetic lethality

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