Discovery Of The Novel Hla-Drb1*09:01:08 Allele In A Taiwanese Volunteer Bone Marrow Donor And Identification Of The Probable Hla-A, Hla-B And Hla-Drb1 Haplotype In Association With Drb1*09:01:08

We report here the novel variant of HLA-DRB1*09:01, DRB1*09:01:08, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*09:01:08 is identical to the sequence of DRB1*09:01:02 in exon 2 except a silent mutation at nucleotide position 261(CT) (GCCGCT at codon 58). We hypothesize DRB1*09:01:08 was probably derived from DRB1*09:01:02 via a nucleotide point mutation event. The plausible HLA-A, HLA-B and HLA-DRB1 haplotype in association with DRB1*09:01:08 was deduced as A*02:07-B*46:01-DRB1*09:01:08.