Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury

Journal of Critical Care(2018)

Cited 5|Views6
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Abstract
•Highly variable volumes of distribution and clearance for IV paracetamol were observed.•Lower Glasgow coma scores were associated with higher clearance of paracetamol.•Paracetamol concentrations were below toxicity threshold with no evidence of accumulation.
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Key words
Brain injury,Paracetamol,Pharmacokinetic,Trauma
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