Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2012)
摘要
Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.
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关键词
asymmetric catalysis,cyclization,radical reactions,reduction,titanium
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