Mitogen-activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) As an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-A]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach.
Journal of medicinal chemistry(2012)
Abstract
A novel class of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) inhibitors was discovered through screening a kinase-focused library. A homology model of MAPKAP-K2 was generated and used to guide the initial SAR studies and to rationalize the observed selectivity over CDK2. An X-ray crystal structure of a compound from the active series bound to crystalline MAPKAP-K2 confirmed the predicted binding mode. This has enabled the discovery of a series of pyrazolo[1,5-a]pyrimidine derivatives showing good in vitro cellular potency as anti-TNF-α agents and in vivo efficacy in a mouse model of endotoxin shock.
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Vascular Targeting Agents
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