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The Calcium-Activated Chloride Channel Anoctamin 1 Acts As a Heat Sensor in Nociceptive Neurons.

Hawon Cho,Young Duk Yang,Jesun Lee, Byeongjoon Lee,Tahnbee Kim,Yongwoo Jang,Seung Keun Back,Heung Sik Na,Brian D Harfe,Fan Wang,Ramin Raouf,John N Wood,Uhtaek Oh

Nature neuroscience（2012）

Cited 313|Views19
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Abstract
This study reports that the Ca 2+ -activated chloride channel anoctamin 1 (ANO1) is activated by heat and is expressed in mouse dorsal root ganglion neurons. Ano1 deletion leads to a deficit in thermal nociception, suggesting that this channel acts as a new heat sensor in pain pathways.
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Key words
Gene expression,Ion channels in the nervous system,Neuronal physiology,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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