The Calcium-Activated Chloride Channel Anoctamin 1 Acts As a Heat Sensor in Nociceptive Neurons.
Nature neuroscience(2012)
Abstract
This study reports that the Ca 2+ -activated chloride channel anoctamin 1 (ANO1) is activated by heat and is expressed in mouse dorsal root ganglion neurons. Ano1 deletion leads to a deficit in thermal nociception, suggesting that this channel acts as a new heat sensor in pain pathways.
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Key words
Gene expression,Ion channels in the nervous system,Neuronal physiology,Biomedicine,general,Neurosciences,Behavioral Sciences,Biological Techniques,Neurobiology,Animal Genetics and Genomics
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