Contribution of itch-associated scratch behavior to the development of skin lesions in -induced dermatitis model in NC/Nga mice
ARCHIVES OF DERMATOLOGICAL RESEARCH(2009)
摘要
Recently, we have reported that the pathophysiological features of dermatitis induced by the repeated application with Dermatophagoides farinae (Df) extract ointment in NC/Nga mice were similar to those observed in the patients with atopic dermatitis. In the present
study, we first examined whether the application of Df in other mouse strains could induce dermatitis. The repeated application
of Df body (Dfb) ointment to the barrier-disrupted back of ICR, C57BL/6, and Balb/c mice did not cause any apparent skin lesions,
although transient increase in serum immunoglobulin E (IgE) levels during antigen application was observed. On the other hand,
in NC/Nga mice, dermatitis scores and serum IgE levels increased remarkably, and then these changes sustained for at least
10 days after stopping of antigen elicitation. Using NC/Nga mice, we investigated the contribution of scratching behavior
to the development and maintenance of Dfb-induced dermatitis. In correlation with the increase in scratching behavior, erythema,
hemorrhage, edema, scarring, erosion and excoriation were observed. Cutting off the hind toenails of mice exhibiting chronic
skin lesions dramatically alleviated the dermatitis. From these findings, the onset of skin lesions and its chronically sustained
course in Dfb-induced dermatitis in NC/Nga mice were closely associated with increased scratching behavior.
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关键词
NC/Nga mice,Dermatophagoides farinae,Scratching,Itch,Atopic dermatitis
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