Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Seminars in Cancer Biology(2008)
Abstract
Upon primary infection, EBV establishes a latent infection in B cells, characterized by maintenance of the viral genome in the absence of viral replication. The Epstein-Barr Nuclear Antigen 1 (EBNA1) plays a crucial role in maintenance of the viral DNA episome and is consistently expressed in all EBV-associated malignancies. Compared to other EBV latent gene products, EBNA1 is poorly recognized by CD8+ T lymphocytes. Recent studies are discussed that shed new light on the mechanisms that underlie this unusual lack of CD8+ T cell activation.
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Key words
EBNA1,BNLF2a,BILF1,BGLF5,BZLF2
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