CJ-21,058, a new SecA inhibitor isolated from a fungus.

Yutaka Sugie, Sae Inagaki,Yoshinao Kato,Hiroyuki Nishida, Chang-Hong Pang,Toshiyuki Saito,Shinichi Sakemi, Fadia Dib-Hajj, John P Mueller, Joyce Sutcliffe,Yasuhiro Kojima

JOURNAL OF ANTIBIOTICS（2010）

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摘要

A new equisetin derivative, CJ-21,058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane.

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Bacterial Adhesin

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