Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients

Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients. A total of 45 genetic markers were genotyped in a Finnish data set comprising 699 IBD patients and 2482 controls. Single-marker association with IBD and its subphenotypes was tested. A meta-analysis with a Swedish UC data set was also performed. A total of 12 single-nucleotide polymorphisms associated with CD and/or UC ( P <0.05). In the subphenotype analysis, rs6974491- ELMO1 ( P =0.0002, odds ratio (OR): 2.20) and rs2298428- UBE2L3 ( P =5.44 × 10 −5 , OR: 2.59) associated with pediatric UC and CD, respectively. In the meta-analysis, rs4819388- ICOSLG ( P =0.00042, OR: 0.79) associated with UC. In the subphenotype meta-analysis, rs1738074- TAGAP ( P =7.40 × 10 −5 , OR: 0.61), rs6974491- ELMO1 ( P =0.00052, OR: 1.73) and rs4819388- ICOSLG ( P =0.00019, OR: 0.75) associated with familial UC, pediatric UC and sporadic UC, respectively. Multiple CelD risk loci also confer susceptibility for CD and/or UC in the Finnish and Swedish populations. Certain genetic risk variants may furthermore predispose an individual for developing a particular disease phenotype.