Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy: in-water synthesis of "difficult sequences".

Keiko Hojo,Hideki Ichikawa, Asaki Hara,Mare Onishi,Koichi Kawasaki,Yoshinobu Fukumori

PROTEIN AND PEPTIDE LETTERS（2012）

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摘要

A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.

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关键词

Solid-phase synthesis,Fmoc-amino acid,synthesis in water,difficult sequence,nanoparticles,microwave-assisted synthesis

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Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy: in-water synthesis of &quot;difficult sequences&quot;.

Aqueous microwave-assisted solid-phase peptide synthesis using Fmoc strategy: in-water synthesis of "difficult sequences".