A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.

Jennifer E Eykelenboom,Gareth J Briggs,Nicholas J Bradshaw,Dinesh C Soares,Fumiaki Ogawa,Sheila Christie,Elise L V Malavasi,Paraskevi Makedonopoulou,Shaun Mackie,Mary P Malloy,Martin A Wear,Elizabeth A Blackburn,Janice Bramham,Andrew M McIntosh,Douglas H Blackwood,Walter J Muir,David J Porteous,J Kirsty Millar

HUMAN MOLECULAR GENETICS（2012）

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摘要

GenBank accession numbers: DISC1FP1 (EU302123), Boymaw (GU134617), der 11 chimeric transcript DISC1FP1 exon 2 to DISC1 exon 9 (JQ650115), der 1 chimeric transcript DISC1 exon 4 to DISC1FP1 exon 4 (JQ650116), der 1 chimeric transcript DISC1 exon 6 to DISC1FP1 exon 3a (JQ650117).

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关键词

transfection,schizophrenia,cos cells,molecular biology,genetics,haploinsufficiency

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