Tracking of systolic blood pressure during childhood: a 15-year follow-up population-based family study in eastern Finland.
JOURNAL OF HYPERTENSION(2002)
摘要
Objectives To investigate the tracking of systolic arterial blood pressure (SBP) during childhood. Design and setting All children born during 1981-82 in a rural community of eastern Finland were followed at the ages of 6 months, 7 and 15 years (SBP-6m, SBP-7y, SBP-15y). One hundred and thirty-eight out of 205 children completed the full follow-up period, of which 100 (45 girls) were included in the analysis with complete data. Main outcome measures SBP (mmHg). Results SBP-6m was associated with SBP-7y (r= 0.715; P< 0.001) and with SBP-15y (r=0.238; P=0.017) and SBP-7y was associated with SBP-15y (r= 0.348; P< 0.001). Adjustment for confounders did not change these results. Children at the highest tertile of SBP-6m had a higher probability of being at the highest tertile of SBP-7y [relative risk (RR) =4.3; 95% confidence interval (CI), (2.4-7.6)] and SBP-15y [RR =1.9; 95% CI, (1.1-3.3)]. Children at the highest tertile of SBP-7y had a higher probability of being at the highest tertile of SBP-15y, [RR = 2.6 (1.5-4.6)]. The regression analysis showed a significant main effect on SBP-15y for birth weight (negative association), male gender, current body mass index (BMI), change of BMI between the ages of 7 years and 15 years, SBP-6m, SBP-7y and the mean SBP between the ages of 6 months and 7 years (all with positive association). Children with family history of hypertension appear to have a higher SBP during childhood; however, this association did not reach a significant level. Conclusions The study confirmed the tracking of SBP during childhood. Birth weight was inversely associated with SBP-15y. Family history of hypertension was not significantly associated with SBP during childhood. J Hypertens 20:195-202 (C) 2002 Lippincott Williams Wilkins.
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关键词
blood pressure,tracking,childhood,birth-cohort,birthweight,hypertension,familial aggregation
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