Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation.

Gulden Camci-Unal,Rahman M Mizanur,Yonghai Chai,Nicola L B Pohl

ORGANIC & BIOMOLECULAR CHEMISTRY（2012）

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摘要

Herein we report the first synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides.

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关键词

fermentation,synthesis,deoxy-d-manno-octulosonic,d-glucose

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