Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists.

Bioorganic & Medicinal Chemistry Letters（2012）

引用 8|浏览15

暂无评分

摘要

A series of 1,3-thiazole derivatives were synthesized as potent, orally bioavailable S1P3-sparing S1P1 agonists. One of them, 24c, exhibited favorable efficacy in rat on host versus graft reaction (HvGR). The pharmacokinetic data for other compounds are shown as well.

查看译文

关键词

S1P1,Agonist,Lymphocyte,HvGR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要