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Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists.

Dramane I Lainé,Hongxing Yan,Haibo Xie,Roderick S Davis,Jeremy Dufour,Katherine L Widdowson,Michael R Palovich,Zehong Wan,James J Foley,Dulcie B Schmidt,Gerald E Hunsberger,Miriam Burman,Alicia M Bacon,Edward F Webb,Mark A Luttmann,Michael Salmon,Henry M Sarau,Sandra T Umbrecht,Philip S Landis,Brian J Peck,Jakob Busch-Petersen

Bioorganic & Medicinal Chemistry Letters（2012）

Cited 9|Views11
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Abstract
Novel tropane-based, ultra long-acting inhaled muscarinic antagonists: preparation, biological evaluation and developability.
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Key words
Inhaled,Muscarinic antagonist,COPD,Tropane,Quaternary ammonium salts
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