Development of a long-term ovine model of cutaneous burn and smoke inhalation injury and the effects of early excision and skin autografting.
Burns(2012)
Abstract
Smoke inhalation injury frequently increases the risk of pneumonia and mortality in burn patients. The pathophysiology of acute lung injury secondary to burn and smoke inhalation is well studied, but long-term pulmonary function, especially the process of lung tissue healing following burn and smoke inhalation, has not been fully investigated. By contrast, early burn excision has become the standard of care in the management of major burn injury. While many clinical studies and small-animal experiments support the concept of early burn wound excision, and show improved survival and infectious outcomes, we have developed a new chronic ovine model of burn and smoke inhalation injury with early excision and skin grafting that can be used to investigate lung pathophysiology over a period of 3 weeks.
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Key words
Wound healing,Wet-to-dry weight ratio,Net fluid balance,Plasma protein,Oncotic pressure,Hematocrit,Neutrophils
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