The biology of protein kinase C.

Lily Zeng, Samuel V Webster,Philip M Newton

CALCIUM SIGNALING（2012）

Cited 81|Views9

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Abstract

This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual isoforms. We then review strategies for inhibiting PKC in experimental systems and finally discuss the therapeutic potential of targeting PKC. Each aspect is covered in summary, with links to detailed resources where appropriate.

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Key words

Kinases,PKC Alpha,PKC Beta,PKC Gamma,PKC Delta,PKC Epsilon,PKC Eta,PKC Theta,PKC Iota,PKC Zeta,PKC Inhibitors

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