Tracking protein aggregation and mislocalization in cells with flow cytometry

Yasmin M Ramdzan,Saskia Polling,Cheryl P Z Chia,Ivan H W Ng,Angelique R Ormsby,Nathan P Croft,Anthony W Purcell,Marie A Bogoyevitch,Dominic C H Ng,Paul A Gleeson,Danny M Hatters

NATURE METHODS（2012）

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摘要

Protein localization changes in cells are monitored at high-throughput applying pulse-shape analysis to flow-cytometry data. The authors use the technique in combination with tetracysteine-based oligomer sensors to monitor toxic protein aggregation in a cellular model of Huntington's disease.

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cell biology,neuroscience

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