Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.

Sujay Basu,Uppuleti Viplava Prasad,Dinesh A Barawkar,Siddhartha De,Venkata P Palle,Suraj Menon,Meena Patel,Sachin Thorat,Umesh P Singh,Koushik Das Sarma,Yogesh Waman,Sanjay Niranjan,Vishal Pathade,Ashwani Gaur,Satyanarayana Reddy,Shariq Ansari

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

A series of novel heterocyclic carboxylic acid based protein tyrosine phosphatase 1B (PTP1B) inhibitors with hydrophobic tail are described. Structure–activity relationship (SAR) optimization resulted in identification of potent, selective and orally bio-available PTP1B inhibitors.

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关键词

Protein tyrosine phosphatase 1B,Diabetes,Carboxylic acid,Heterocycle,Metabolic stability

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