Community-associated methicillin-resistant Staphylococcus aureus endocarditis 'down under': case series and literature review.
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES(2012)
Abstract
Infective endocarditis is a common complication of Staphylococcus aureus bacteraemia, but literature reports of community-associated methicillin-resistant S. aureus (CA-MRSA) endocarditis are relatively uncommon and mostly comprise intravenous drug users (IVDUs) with the USA300 strain. We report 5 cases of CA-MRSA endocarditis in previously healthy young Australian adults, 4 in IVDUs. Morbidity was high with frequent septic emboli; 3 patients required cardiac surgery and 1 patient died. Typing revealed the 2 most common Australian strains, the Panton-Valentine leukocidin (PVL)-positive ST93 (Queensland) strain and the PVL-negative ST1 (WA-MRSA-1) strain.
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Key words
Endocarditis,Staphylococcus aureus,methicillin resistance,community-associated,vancomycin
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