Chromatin-modifying enzymes as modulators of reprogramming

Tamer T. Onder,Nergis Kara,Anne Cherry,Amit U. Sinha,Nan Zhu,Kathrin M. Bernt,Patrick Cahan,B. Ogan Mancarci,Juli Unternaehrer,Piyush B. Gupta,Eric S. Lander,Scott A. Armstrong,George Q. Daley

NATURE（2012）

引用 753|浏览59

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摘要

Inhibition of DOT1L, the H3K79 histone methyltransferase, increases cell reprogramming and substituted for KLF4 and c-Myc, showing that chromatin-modifying enzymes act not only as facilitators but also as barriers to reprogramming.

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Stem cells

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