Aminopyrimidinone cdc7 kinase inhibitors.

Keith W Woods,Chunqiu Lai,Julie M Miyashiro,Yunsong Tong,Alan S Florjancic,Edward K Han,Niru Soni,Yan Shi,Loren Lasko,Joel D Leverson, Eric F Johnson,Alexander R Shoemaker,Thomas D Penning

Bioorganic & Medicinal Chemistry Letters（2012）

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摘要

We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (Ki) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds to inhibition of MCM2 phosphorylation.

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关键词

Cdc7,Kinase,Pyrimidinone,Azaindole,Cancer

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