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Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells.

Ayaka Hosoki,Shin-Ichiro Yonekura,Qing-Li Zhao,Zheng-Li Wei,Ichiro Takasaki,Yoshiaki Tabuchi,Li-Li Wang,Shiga Hasuike,Takaharu Nomura,Akira Tachibana,Kazunari Hashiguchi,Shuji Yonei,Takashi Kondo,Qiu-Mei Zhang-Akiyama

Journal of Radiation Research（2012）

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Abstract
Reactive oxygen species (ROS) act as a mediator of ionizing radiation-induced cellular damage. Previous studies have indicated that MnSOD (SOD2) plays a critical role in protection against ionizing radiation in mammalian cells. In this study, we constructed two types of stable HeLa cell lines overexpressing SOD2, HeLa S3/SOD2 and T-REx HeLa/SOD2, to elucidate the mechanisms underlying the protecti...
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Key words
SOD2,Mitochondria,Radiation protection,Oxidative stress,2',7'-dichlorofluorescein,Regulation of geneexpression,Pathway analysis
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