Instrumented roll technology for the design space development of roller compaction process.

Instrumented roll technology on Alexanderwerk® WP120 roller compactor was developed and utilized successfully for the measurement of normal stress on ribbon during the process. The effects of process parameters such as roll speed (4–12rpm), feed screw speed (19–53rpm), and hydraulic roll pressure (40–70bar) on normal stress and ribbon density were studied using placebo and active pre–blends. The placebo blend consisted of 1:1 ratio of microcrystalline cellulose PH102 and anhydrous lactose with sodium croscarmellose, colloidal silicon dioxide, and magnesium stearate. The active pre-blends were prepared using various combinations of one active ingredient (3–17%, w/w) and lubricant (0.1–0.9%, w/w) levels with remaining excipients same as placebo.